Pyrazinone protease inhibitor metabolites from Photorhabdus luminescens
نویسندگان
چکیده
منابع مشابه
A zinc metalloprotease inhibitor, Inh, from the insect pathogen Photorhabdus luminescens.
The entomopathogen Photorhabdus luminescens secretes many proteins during the late stages of insect larvae infection and during in vitro laboratory culture. The authors have previously characterized and purified a 55 kDa zinc metalloprotease, PrtA, from culture supernatants of P. luminescens. PrtA is secreted via a classical type I secretory pathway and is encoded within the operon prtA-inh-prt...
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Photorhabdus luminescens is a nematode-symbiotic, gram negative, bioluminescent bacterium, belonging to the family of Enterobacteriaceae. Recent studies show the importance of this bacterium as an alternative source of insecticides, as well as an emerging human pathogen. Various toxins have been identified and characterized in this bacterium. These toxins are classified into four major groups: ...
متن کاملPleiotropic role of quorum-sensing autoinducer 2 in Photorhabdus luminescens.
Bacterial virulence is an integrative process that may involve quorum sensing. In this work, we compared by global expression profiling the wild-type entomopathogenic Photorhabdus luminescens subsp. laumondii TT01 to a luxS-deficient mutant unable to synthesize the type 2 quorum-sensing inducer AI-2. AI-2 was shown to regulate more than 300 targets involved in most compartments and metabolic pa...
متن کاملAnaerobic metabolism of primary and secondary forms of Photorhabdus luminescens
An oxygen electrode inserted into a dead Munducu sex~u larva infected with Heterorhabditis nematodes carrying the bacterium Photorhabdus luminescens showed barely detectable levels of oxygen in a 1 to 2 mm zone below the cuticle, and virtual anaerobiosis deeper in the carcass. This observation indicates that the bacteria in this habitat, where they are actively growing, are probably carrying ou...
متن کاملSecreted proteases from Photorhabdus luminescens: separation of the extracellular proteases from the insecticidal Tc toxin complexes.
Photorhabdus luminescens secretes both high molecular weight insecticidal toxin complexes and also a range of extracellular proteases into culture broth. Previous studies by others have suggested that insecticidal activity of the broth is associated with these proteases. However, by gene cloning and targeted knock-out, we have previously shown that oral insecticidal activity is associated with ...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 2016
ISSN: 0021-8820,1881-1469
DOI: 10.1038/ja.2016.79